Formulation Development and Evaluation of Fast Dissolving Films of Oloptadine HCl Varsha Ahirwar1,2,*, Yadav Khushwant S.1,2, Dr., Bindaiya Shailendra1,2, Dr. 1Rajeev Gandhi College of Pharmacy, Bhopal (M.P) 2Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.) *Corresponding Author E-mail: varsha.ahirwar2010@gmail.com
Abstract Our studies on the performance of formulation development and evaluation of fast dissolving films of Oloptadine HCL its anti-allergic drug. Prepare mouth dissolving film of Oloptadine HCl by solvent casting method. To characterize the prepared mouth dissolving film of Oloptadine HCL in terms of— Thickness, percent elongation, tack test, swelling index, in-vitro disintegration time and dissolution test. Oloptadine OLO), 11-[{z}- 3-(Dimethlamino) propylidene]-6-11-dihydrobenz [b, e] oxepin-2-acetic acid hydrochloride, is widely used as an antihistaminic. Oloptadine HCL is a relatively selective histamine H1-receptor antagonist that inhibits the release of histamine from mast cells. Oloptadine does not affect alpha-adrenergic dopamine, muscarinic type 1 and 2 or serotonin receptor. They are hydrophobic in nature and non-polar, sparingly soluble in water and freely soluble methanol, ethanol. Olopatadine HCl is a mouth dissolving film. We is trying to sort out the problem of allergic. They are rapidly onset of action, when placed upon the tongue that it is disperse rapidly swallowing within 3 -5 seconds without need of water or chewing. Top Keywords Fast dissolving film, Solvent casting method, Freely soluble, Onset of action. Top |