Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole Pandey Alok1,*, Verma Shekhar2, Dubey Ravindra Dhar2, Dewangan Dhansay1, Patel Vidyanand2, Deshmukh Keshav2 1Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52, Tamilnandu, India 2Institute of Pharmacy, RITEE, Mandir Hasaud, Chhatauna, Raipur -492101 (C.G.), India *Corresponding Author E-mail: aalokpandey444@gmail.com
Online published on 6 March, 2013. Abstract Schiff Bases of 2-amino-5-aryl-1, 3, 4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1, 3, 4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against Swiss albino mice, anti-inflammatory activity against Wister albino rats. Top Keywords Schiff base, 1,3,4-thiadiazole, Analgesic, Anti-inflammatory activity. Top |