RP-HPLC Method for the Estimation of Domperidone in Bulk and Pharmaceutical Formulations Rajendraprasad Y1, Rajasekhar KK2,*, Shankarananth V2, Kumar S Bharath2, Kumar G Dileep2, Sreelekha T2 1Department of Pharmaceutical Chemistry, AU college of Pharmaceutical Sciences, Andhra University, Vishakapatnam-530003, A.P, India 2Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupati-517503, Andhra Pradesh India *Corresponding Author E-mail: kkrspsp@yahoo.co.in
Online published on 13 March, 2013. Abstract The Present work describes a simple reverse phase HPLC method for the estimation of Domperidone in bulk and pharmaceutical formulations. The estimation was carried out on Gemini, Phenomonex, C-18 (250x4.6 mm, 5μ) column using a mobile phase consisting of potassium dihydrogen phosphate buffer-Acetonitrile-Methanol (40:30:30). The eluent was monitored at 288 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method. Top Keywords HPLC estimation, Validation, Domperidone, Pharmaceutical formulation. Top |