Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity Pattan Shashikant R1,*, Dighe Nachiket S1, Bukitagar Anand A, Chavan Prerana A1, Tambe Snehlata K1, Musmade Deepak S1, Hiremath S V2 1Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India 2Department of Pharmacology, JNMC, Belgaum, Karnataka *Corresponding Author E-mail: shashipattan@yahoo.com
Online published on 13 March, 2013. Abstract A new series of substituted phenylthiazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-convulsant activity by Maximal Electroshock Induced Convulsions in Rats, Pentylenetetrazole-Induced Convulsions in Rats, and Strychnine Induced Convulsions in Rats methods. Compounds C1, C2, C3, C4, C5, D1, D2, D3, D4, D5, E1, E2, E3, and E4 have been found to exhibit excellent anti-convulsant activity. Top Keywords Phenylthiazole, Anti-convulsant. Top |