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Synthesis and Antibacterial Evaluation of Some Novel PhenylthiazolylQuinqzolin-4(3h)-One Derivative Badwaik Hemant*, Sonkar Sandeep, Singh Mukesh, Rajpal Suresh, Sisodiya Dharamveer, Pandey Ajit Ultra College of Pharmacy, Madurai, Tamil Nadu *Author E-mail: ssonkar12@gmail.com
Online published on 13 March, 2013. Abstract The present work deals with synthesis and evaluation of some novel phenylthiazole and quinazoline combination derivatives of biological interest. The reaction of acetophenone with thiourea formed 4-phenylthiazol-2-amine (I) was refluxed with N-chloroacetyl anthranillic acid (II)in the presence of K2CO3 in dry ethanol under anhydrous condition yields 2-chloromethyl-3-[4-(phenyl) thiazol-2-yl]-quinazolin -4(3H) one(III). The 2-chloromethyl-3-[4-(phenyl)thiazol-2-yl]quinazolin-4(3H)–one(III) and respective aromatic amines was refluxed in dry pyridine and acetic anhydride formed N-3-[4-(4–phenyl) thiazol–2–yl]-[2-(substituted amino) methyl] quinazoline–4 (3H)-one derivatives (IV).The synthesized compounds are to be screened for antibacterial activity. Top | |
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