Synthesis and Biological Screening of Some Novel 4-Thiazolidinone Derivatives Muthumani P*, Meera R, Pratesh, Chidambaranathan N, Devi P, Bkameswari K.M. College of Pharmacy, Uthangudi, Madurai – 625 107. TamilNadu, India *Corresponding Author E-mail: sabareesanmuthu@gmail.com
Online published on 13 March, 2013. Abstract A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff's bases with thiooglycollic acid. The substituted schiff's bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity. Top Keywords Substituted 4-thiazolidinonnes, Anticonvulsant, Anti hyperglycemic, Anti bacterial. Top |