Asian Journal of Research in Chemistry
Year : 2009, Volume : 2, Issue : 4
First page : ( 523) Last page : ( 525)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.

Synthesis, Identification of Some P-Chiral Organic Phosphoramidates and Their Inhibitory Action towards Enzymes

Singh Soram Ibomcha, Prabha Shashi*

School of Studies in Chemistry, Jiwaji University, Gwalior-474011

*Corresponding Author E-mail: ibomsoram@yahoo.co.uk

Online published on 13 March, 2013.

Abstract

Phosphoramidates (N-P) are biologically active organic compounds because they are capable of inhibiting enzyme action. A few members of this class were synthesized and checked for their anticholinesterase properties and they were found to be a good reactive phosphorylating agent to block AChE rather than BuChE in the poisoning process. The presence of chloro-substituent (either ortho-or para-) in the aryl moiety of these phosphoramidates does not show any significant contribution during toxicological study made in vitro. These phosphoramidates were characterized by FT-IR, ³¹P NMR and GC-MS spectral studies.

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Keywords

Phosphorylation, phosphoramidates, anticholinesterase, ³¹P NMR, toxicity.

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