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Synthesis and Biological Screening of Some New Series of Aryl Thiazole Derivatives Basawaraj Raga*, Shabbir Majid Post-Graduate Centre, Dept. of Pharmaceutical Chemistry, Karnataka College of Pharmacy, Manahalli Road, Bidar-585403 *Corresponding Author E-mail: ragabv@rediffmail.com
Online published on 13 March, 2013. Abstract 2-Arylamino/arylidinehydrazino-4-(4-methoxyphenyl-2-yl) thiazoles were obtained by the reaction of 1-bromoacetyl-4-methoxyphenyl with various substituted arylthioureas and arylidinethiosemicarbazides in ethanol. Aminogroup of aryl thiazole have been treated with different aromatic aldehydes afford corresponding schiff bases, which on further treated with chloroacetylchloride and mercaptoacetic acid converted to corresponding azetidinones and thiazolidinones. All the compounds were characterized on basis of analytical and spectral data and these compounds were screened for invitro antimicrobial activity. Top Keywords Arylthiazole, Schiff's bases, Azetidinones, Thiazolidinones, Antimicrobial activity. Top | |
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