Synthesis and Anti-Bacterial Study of 4-(4-Substituted Phenyl)-5,6Disubstituted-1-(4-Substituted Phenyl Thiazol-2-yl) Pyridin-2 (1H)-One Patel Vimal I*, Patel Harsha U, Patel Chhaganbhai N, Suthar Kiran J Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind baug, Mehsana-384001, Gujarat, india *Corresponding Author E-mail: patelvimal95@yahoo.com
Online published on 13 March, 2013. Abstract 4-(4-Substituted Phenyl)-5,6-Disubstituted-1-(4-Substituted Phenyl Thiazol-2-yl)Pyridin-2(1H)-One have been prepared from citric acid.it is treated withconc. H2SO4 and then with phenetole to give β-arylglutaconic acid which on fusion with 2-amino 4-substituted Phenyl thiazole results in 4-(4-substitutedphenyl)-1-(4-substitutedphenylthiazol-2-yl)pyridine-2,6(1H,3H)-dione. Then reacted with phosphorous oxychloride, it give 5,6-dichloro-4-(4-substituted phenyl)-1-(4-substituted phenyl thiazol-2-yl) pyridin-2(1H)-one. Which on treatment with secondary amines Yields 4-(4-Substituted phenyl)-5,6-Disubstituted-1-(4-Substituted-Phenyl thiazol-2-yl)Pyridin-2(1H)-One. All the title compounds characterised on the basis of their IR, MASS, 1H NMR spectroscopic data analysis. Top Keywords Synthesis, Thiazole, β-Arylglutaconic Acid, Secondary Amines, Anti-Bacterial activity. Top |