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Estimation of Cefixime and Erdosteine in its Pharmaceutical Dosage Form by Spectrophotometric Method Nanda RK*, Gaikwad J, Prakash A, Ghosh VK, Nagore DH Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune *Corresponding Author E-mail: anand_pharma2008@rediffmail.com
Online published on 13 March, 2013. Abstract Two accurate and precise methods were developed for the estimation of Cefixime and Erdosteine in its pharmaceutical dosage form. First method is area under the curve method; the areas under the curve in the range of 294.5–284.5 nm (for CEF) and 240.0–230.0 nm (for ERD) were selected for the analysis. Second method is first order derivative spectroscopy by solving simultaneous equation, 309.0 nm (for CEF) and 227.5 nm (for ERD) were selected for the analysis. In both the methods linearity for detector response was observed in the concentration range of 10–50 μg/ml for both Cefixime and Erdosteine. The proposed methods were successfully applied for the simultaneous determination of both drugs in its pharmaceutical preparation. The results of the analysis have been validated statistically and by recovery studies. Top Keywords Cefixime; Erdosteine, area under the curve method, derivative spectroscopy. Top | |
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