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Development and Validation of Method for Simultaneous Estimation of Atenolol and Lercanidipine from Tablet Dosage Form by Second Order Derivative Spectroscopy Bhatia Neela M*, Gavali A Y Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013 *Author E-mail: ashutoshgavali@gmail.com
Online published on 13 March, 2013. Abstract Atenolol and Lercanidipine are used in combination for treatment of hypertension. The present work deals with simple spectrophotometric method development for simultaneous estimation of Atenolol (ATN) and Lercanidipine (LER) in tablet formulation. The method employed second order derivative spectroscopy1. For determination of sampling wavelength 10 μg/ml of each of ATN and LER were scanned in 200–350 nm range and sampling. The values of 2D amplitudes were measured 275 nm (zero crossing of LER) and 322nm (zero crossing of ATN) for the determination of ATN and LER, respectively. For this method linearity was observed in 10–60 μg/ml for ATN and 10–60μg/ml for LER. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method. The method is validated as per ICH guidelines. Top Keywords Atenalol, Lercanidipine, UV-Derivative spectroscopy, Validation. Top | |
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