Synthesis and In-Vitro Antimicrobial Activity of 4-(Piperazin-1- Ylcarbonyl) Aniline – An Amide Derivative of P-Aminobenzoic Acid Kulkarni Swapna S1, Mehere AP, Shenoy Priyank A1,* 1Alard College of Pharmacy, Sr.no 50, Marunje, Rajiv Gandhi Infotech Park, Pune-411057, Maharashtra, India Sharad Pawar College of Pharmacy, Wanadongari, Nagpur, Maharashtra, India *Corresponding Author E-mail: priyank.shenoy@rediffmail.com
Online published on 13 March, 2013. Abstract An amide derivative of P-aminobenzoic acid (PABA) has been synthesized from piperazine by initial conversion of PABA into its hydrochloride salt for protection of amino group from self-polymerization. The compound identity has been characterized by Melting point, Elemental Analysis, TLC, UV-Visible spectroscopy, IR spectroscopy and NMR spectroscopy. The antibacterial activity of the compound has been studied against E.coli, S.aureus, B.subtilis and P.aeruginosa using tetracycline as a standard. Antifungal activity of the compound has been studied against C.albicans and A.niger using clotrimazole as a standard. The synthesized compound has been found to possess significant antibacterial and antifungal activities as compared to the standard drugs used. Top Keywords Amide derivative, PABA, Self-Polymerization, Antibacterial, Antifungal. Top |