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Research Journal of Topical and Cosmetic Sciences
Year : 2018, Volume : 9, Issue : 2
First page : ( 49) Last page : ( 52)
Print ISSN : 0976-2981. Online ISSN : 2321-5844.
Article DOI : 10.5958/2321-5844.2018.00010.9

Formulation and Evaluation of Topical Antifungal Gel Containing Itraconazole

Kasar Poonam Madhukar*, Kale Kalyani Sundarrao, Phadtare Dipti Ganesh

R.G.S Institute of Pharmacy, Anjaneri, Nashik, Maharashtra, India

*Corresponding Author E-mail: sonikasar2706@gmail.com

Online published on 22 May, 2019.

Abstract

The present research has been undertaken with the aim to develop a topical gel formulation of Itraconazole. Itraconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Itraconazole is not much recommended as it has many side effects. Commercially Itraconazole topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by changing the polymer ratio. Formulation were evaluated for % yield, spredability, extrudability, washability and viscosity in-vitro drug release study, skin irritation study, stability testing and finally it was concluded that formulation F3 was the best formulation among these formulation.

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Keywords

Itraconazole, Carbopol 934p, HPMC.

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