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Research Journal of Topical and Cosmetic Sciences
Year : 2019, Volume : 10, Issue : 2
First page : ( 48) Last page : ( 56)
Print ISSN : 0976-2981. Online ISSN : 2321-5844.
Article DOI : 10.5958/2321-5844.2019.00011.6

Bacteriostatic activity of Melaleuca alternifolia loaded Microemulsion targeting microbial skin infection by Topical Delivery

Pant Arushi, Agarwal Shriya, Singh Manisha*

Department of Biotechnology, Jaypee Institute of Information Technology, JIIT, Noida, Uttar Pradesh, India

*Corresponding Author E-mail: manishasingh1295@gmail.com

Online published on 18 April, 2020.

Abstract

Objective-Essential oils (EOs)are highly volatile and concentrated phytocompounds with a wide range of health benefits that range from being a potential anti-microbial, antioxidant to an anti-inflammatory agent. Similarly, Tea tree oil (TTO) is one such therapeutically important EO exhibiting marked therapeutic benefits against dermal disorders such as eczema, cellulitis, psoriasis, acne, fungal infections, and even dermal cancers. Since TTO has high volatility and irritability which restricts for direct dermal application and get decomposed easily due to external factors. Therefore, to overcome these limitations, TTO loaded oil in water microemulsion system (TTO ME) was fabricated and its antimicrobial and antioxidant properties were compared with TTO itself. Methods-The already prepared Microemulsions were subjected to antioxidant and antimicrobial analysis. Results-The results showed significant microbial inhibition by TTO ME in comparison to TTO and positive controls in Staphylococcus aureus and Micrococcus luteus sp. Also, antioxidant assays exhibited a higher quenching ability of TTO ME. Conclusion-The obtained results suggested TTO ME to be efficacious and stable microemulsion based nano-formulation for dermal infections.

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Keywords

Nano-formulation, dermal infections, antioxidant ability, antimicrobial activity, tea tree oil.

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