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Research Journal of Science and Technology
Year : 2017, Volume : 9, Issue : 3
First page : ( 308) Last page : ( 312)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2017.00055.9

Development and Validation of Gas Chromatography/Mass Spectrometry Method for the Simultaneous Determination of Some Preservatives in Personal Care, Cosmetics and Pharmaceutical Formulations

Bajaj Atul*, John Cijo, Choudhury Joydip, Tripathi Rohitashva Mani

Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh, India-160036

*Corresponding Author E-mail: atulbajaj37@gmail.com

Online published on 12 June, 2018.

Abstract

The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R2) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.

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Keywords

Cosmetics, pharmaceuticals, personal care products, Parabens, GC-MS, preservatives.

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