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Research Journal of Science and Technology
Year : 2017, Volume : 9, Issue : 3
First page : ( 308) Last page : ( 312)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2017.00055.9

Development and Validation of Gas Chromatography/Mass Spectrometry Method for the Simultaneous Determination of Some Preservatives in Personal Care, Cosmetics and Pharmaceutical Formulations

Bajaj Atul*, John Cijo, Choudhury Joydip, Tripathi Rohitashva Mani

Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh, India-160036

*Corresponding Author E-mail: atulbajaj37@gmail.com

Online published on 12 June, 2018.


The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R2) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.



Cosmetics, pharmaceuticals, personal care products, Parabens, GC-MS, preservatives.


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