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Research Journal of Science and Technology
Year : 2016, Volume : 8, Issue : 3
First page : ( 155) Last page : ( 162)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2016.00022.X

Hot Melt Extrusion Technique-A Review

Bhairav Bhushan A.1,*, Kokane Prajakta A.1, Saudagar Ravindra B.2

1Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik

2Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik

*Corresponding Author E-mail:

Online published on 18 October, 2016.

Abstract

Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems. HME is a solvent free process that achieves solid molecular dispersions by a melt blending process, in which the API is dispersed and or dissolved into a polymeric matrix. HME is an excellent alternative to other conventionally available techniques such as roll spinning and spray drying. In This paper we review about the types of Extruder, solid dispersion and Application of the HME to the pharmaceutical industries.

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Keywords

Hot melt Extrusion, Equipment and Process, Application.

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