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Research Journal of Science and Technology
Year : 2016, Volume : 8, Issue : 1
First page : ( 1) Last page : ( 4)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2016.00001.2

Spectrophotometric Method Development and Validation of Prazosin

Nikam Pooja1, Baokar Shrikrishna1,*, Undare Santosh2, Patil R.N.1

1Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal's College of Pharmacy, Malegaon (Bk), Tal-Baramati, Dist-Pune, Maharashtra, India-413115

2PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal's Balbhim Arts, Science and Commerce College, Beed, Maharashtra, India-431112

*Corresponding Author E-mail: krishnabaokar@gmail.com

Online published on 18 April, 2016.


Prazosin Hydrochloride (PRZ) is an antihypertensive agent which is one of the leading marketed drugs in the world. A rapid, specific and economic UV spectrophotometrically method has been developed using methanol as a solvent to determine the PRZ content in bulk and pharmaceutical dosage formulations. At a pre-determined Λmax of 2 nm, it was proved linear in the range of 1 -5 μg/mL, and exhibited good correlation coefficient (R2=0.999) and excellent mean recovery. This method was successfully applied to the determination of PRZ content in one marketed brand from India and the results were in good agreement with the label claim. The method was validated statistically and by recovery studies for linearity, precision, accuracy, ruggedness, robustness, LOD and LOQ. The obtained results proved that this method can be employed for the routine analysis of PRZ in bulks as well as in the commercial formulations.



UV-spectrophotometer, Prazosin, Antihypertensive agent.


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