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Research Journal of Science and Technology
Year : 2020, Volume : 12, Issue : 3
First page : ( 195) Last page : ( 200)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2020.00027.3

Validation of fgfcf and ammonium molybdate in visible spectrophotometric determination of eletriptan hydro bromide

Acharyulu M.L.N.1,*, Rao P.V.S.R. Mohana2, Ramakoti I. Siva3, Jayarangarao P.4

1Associate Professor, Centurion University of Technology and Management, Andhra Pradesh-530017, India

2Research Scholar, Department of Engineering Chemistry, A.U. College of Engineering (A), Visakhapatnam, Andhra Pradesh-530017, India

3Assistant Professor, Centurion University of Technology and Management, Parlakhimundi, Village Alluri Nagar, R. Sitapur, Odisha, 761211, India

4Assitant Professor, Baba Institute of Technology and Sciences, Visakhapatnam, Andhra Pradesh, India-530041

*Corresponding Author E-mail: acharyulu@cutmap.ac.in

Online published on 16 September, 2020.

Abstract

Two simple and sensitive visible spectrophotometric methods (A and B) for the assay of Eletriptan Hydro Bromide (EHB) in pure and pharmaceutical formulations were developed. Method A is based on oxidation of the drug with oxidant Potassium permanganate, followed by the estimation of un reacted oxidant with Fast green FCF (FGFCF),at a λmax 622nm. Method-B depends on reduction of 1, 2 or 3 oxygen atoms from Molybdate by the acid hydrolysis products of paraxetine (catechol unit and formaldehyde) of the drug producing one or more of the possible reduced species which has a characteristic intense green colour measured at λmax 641nm against a reagent blank. The amount of EHB in both methods were obtained from the Beers-Lambert's plot. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges for method A, and B are (4–24) μg/ml,(10–60) μg/ml, correlation co-efficient are 0.9992,0.9968 respectively. The Sandell's sensitivities are 1.3738 x 10−2 (1 mole cm−1) for both methods and molar absorptivity values 6.8549 x 105 and 1.2115 x 105(μg cm−2). The proposed methods are applied to commercially available formulations and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. These methods are applied successfully for the estimation of the Eletriptan Hydrobromide in the presence of other ingredients that are usually present in formulations. These methods offer the advantages of rapidity, simplicity and sensitivity and low cost without the need for expensive instrumentation and reagents.

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Keywords

Formulations, Correlation Coefficient, Regression analysis.

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