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Research Journal of Science and Technology
Year : 2020, Volume : 12, Issue : 3
First page : ( 173) Last page : ( 176)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2020.00023.6

In vitro anticancer activity of Majidea zanquebarica J. Krik. ex Oliv. (Sapindaceae)

Gowri S. Shyamala*

PG and Research Department of Botany, Pachaiyappa's College, Chennai-600030

*Corresponding Author E-mail: shyamalagowri1985@gmail.com

Online published on 16 September, 2020.

Abstract

The present study was designed to evaluate the in vitro cytotoxicity activity of hexane, 70% methanolic extract and bark hexane extract of M. zanquebarica. In this study the extract was tested using Human cancer cell lines, such as PC-3 (Prostate carcinoma), A-431 (Epidermoid carcinoma), HeLa (Human cervical carcinoma) and MCF (Breast cancer) for their effects on cell viability, growth inhibition and cell morphology. Cell viability and inhibition were determined by MTT [(3,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)] assay. Hexane bark extract had shown more percentage of inhibition on A431 cell lines. Out of the different concentrations used, the hexane extract showed IC50 value of 100 μg/ml concentration in all the cell lines. The result implicated that hexane extract was more pronounced with more activity against all the cancer cell lines.

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Keywords

M. zanquebarica, MTT-assay, A431, HeLa, PC-3 and MCF.

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