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Research Journal of Science and Technology
Year : 2020, Volume : 12, Issue : 1
First page : ( 36) Last page : ( 46)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2020.00004.2

Analytical Method Development and Validation of Rivaroxaban-A Review

Deokar Anuja Uddhav1,*, Dr Siddheshwar Suhas2, Kakad Sudarshan. B.3

1Research Scholar, M Pharmacy, Pravara Rural College of Pharmacy, Pravaranagar

2Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar

3Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar

*Corresponding Author E-mail: deokaranuja95@gmail.com

Abstract

Rivaroxaban is oxazolidine derivatives having anticoagulant activity. In literature few analytical methods are discussed for the estimation of Rivaroxaban. The objective of this study is to develop and validate RP-HPLC method for the qualitative estimation of the drug. In most of the methods, the isocratic elution was carried out by using Acetonitrile, water and buffer as a mobile phase. The wavelength was in between 245 to 252 nm. The flow rate was approximately 1.0 ml/min. the temperature set was ambient temperature. The developed methods were validated as per ICH guidelines and this methods were found to be specific, precise, sensitive and robustness.

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Keywords

Rivaroxaban, oxazolidine, RP-HPLC method, Anticoagulant, Validation. System suitability. Stability-indicating. Pharmaceutical dosage form, ICH.

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