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Research Journal of Science and Technology
Year : 2019, Volume : 11, Issue : 2
First page : ( 109) Last page : ( 112)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2019.00017.2

Effect of Azima tetracantha Lam on Human Breast Cancer Cells MCF-7

Jose B. Edwin1, Dr. Muralidharan P.2,*

1Department of Pharmaceutical Chemistry, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi

2Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Chennai

*Corresponding Author E-mail: meeraharsa23@gmail.com

Online published on 22 May, 2019.

Abstract

Current clinical trends involve the usage of plants as therapeutic agents in a wide range of applications. Present investigation is focused on the anticancer activity of the ethyl acetate extract and isolated compounds II, III of Azima tetracantha against MCF-7 cell line. The study was facilitated by collecting the plant sample and subjected to ethanol extraction using Soxhlet apparatus. The anticancer activity of the extracted sample against MCF-7 cell line was examined by MTT assay. The study confirms that the leaf extract of Azima tetracantha has pronounced anticancer potential against MCF-7 cell lines while compared to that of the stem extract. The plant investigated possesses remarkable anticancer activity and hence isolation of the compound contributing to the activity may lead to develop at a novel and natural phytomedicine for the disease.

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Keywords

Azima tetracantha, MCF-7 cell line, MTT assay, anti-cancer activity.

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