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Research Journal of Science and Technology
Year : 2019, Volume : 11, Issue : 1
First page : ( 77) Last page : ( 81)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2019.00012.3

Estimation of Almotriptan malate in tablets by sensitive Visible Spectrophotometric method

Ramu B. Kalyana1,*, Bab M. Syam2,*, Prasad U. Viplava2, Babu P. Konda3

1Department of Chemistry, Maharajah's College (Aided and Autonomous), Vizianagaram-535002 (AP) India

2Department of Organic Chemistry and Analysis of Foods Drugs and Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003, Andhra Pradesh (India)

3Department of Statistics, Maharajah's College (Aided and Autonomous), Vizianagaram-535002 (AP) India

*Corresponding Author E-mail: kalyanaramu23566@gmail.com, msyambab@gmail.com

Online published on 16 March, 2019.

Abstract

A simple, sensitive indirect visible spectrophotometric method has been developed for the estimation of almotriptan malate either in bulk or tablet dosage forms. The method is based on the oxidation of drug with excess N-Bromo succinimide and determining the unreacted NBS with reagents PMAP-SA by spectrophotometrically at 520nm Beer's law obeyed in the concentration range of 4–20 μg/ml. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing AXERT tablets containing AM. The statistical data indicates the accuracy, reproducibility and the precision of the proposed method.

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Keywords

Determination, Beer's Law, Charge-transfer complex formation, Spectrophotometer, Statistical analysis, Tablets.

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