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Research Journal of Science and Technology
Year : 2019, Volume : 11, Issue : 1
First page : ( 59) Last page : ( 63)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2019.00008.1

Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC

Godge Rahul K.*, Shinde Ganesh S., Joshi Shraddha

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India

*Corresponding Author E-mail: Rahul_godge@rediffmail.com

Online published on 16 March, 2019.


A simple, rapid, precise, accurate RP-HPLC method has been developed and validated to estimate Saxagliptin hydrochloride and Dapagliflozin in bulk and in dosage form. The samples were eluated Grace C18 (250mm x 4.6 ID, Particle size: 5micron with mobile phase Methanol: water (pH adjusted to 3 with potassium dihydrogen orthophosphate) (80: 20) at wavelength 225nm. A good linear response was obtained in the range from 10–50μg/mL for Saxagliptin hydrochloride and Dapagliflozin. The method was quantitatively evaluated in terms of linearity, precision, accuracy (recovery), selectivity and robustness as per USP guideline.



Saxagliptin, Dapagliflozin, RP-HPLC.


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