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Research Journal of Science and Technology
Year : 2019, Volume : 11, Issue : 1
First page : ( 1) Last page : ( 8)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2019.00001.9

Polymorphism Study of TCF7L2 gene and related to some biochemical parameters in DM2 females Iraqi patients

Ahmed Najwa Sh1, Hadi Yasmin Ali1, Dhefer Iqbal Hanash2,*

1Biotechnology Research, Molecular and Biotechnology Laboratory, AL-Nahrain University, Baghdad, Iraq

2Nursing Department, AL-Suwaira Technical Institute, Middle Technical University

*Corresponding Author E-mail: iqbal_defer@yahoo.com, iqbal.hanash@instituteofsuwaria.com

Online published on 16 March, 2019.

Abstract

Transcription factor7 like 2 gene (TCF7L2) genomic polymorphisms are scanned to be powerfully related to diabetes mellitus type 2 (DM2) in female Iraqi population. The goal of this paper was to analyze the correlation of TCF7L2 gene polymorphisms with DM2 in a very female public of AL-Iraq. Techniques: 70 DM2 female patients and 60 healthy samples were chosen for the current study. Has been conducted designedly of one primer for amplification to scan the gene and using PCR technique with sequencing. We tend to measure the concentration of blood urea nitrogen, triglyceride total cholesterol, low density lipoprotein, high density lipoprotein, fasting glucose and creatinine in serum by utilizing equipment for chemical examination. Results: For total participants, the (G/A vs. AG + GT) were significantly greater in samples with DM2 than in healthy controls, and following some factors, like serum concentration of TC, TG, LDL, and HDL for DM2, the difference in significant was found. This result revealed that the risk of DM2 was raised with the existence of the GA and GT genotype of TCF7L2 gene in Iraqi female. The G allele frequency of TCF7L2 gene was greater in DM2 patients than in healthy control samples. Conclusions: Our analysis proposed that the TCF7L2 gene genetic polymorphisms were related with DM2 in the female populace of Iraq.

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Keywords

DM2, polymorphism, TCF7L2, triglyceride, total cholesterol.

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