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Research Journal of Science and Technology
Year : 2018, Volume : 10, Issue : 2
First page : ( 145) Last page : ( 156)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2018.00022.0

Gastro Retentive Drug Delivery Systems-a Novel Approaches of Controlled Drug Delivery Systems

Bhowmik Debjit1,*, Bhanot Rishab1, Gautam Darsh1, Rai Parshuram1, Kumar K. P. Sampath1

Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H. P.

1Department of Pharmacy, Coimbatore government medical college, Coimbatore

*Corresponding Author E-mail: debjit_cr@yahoo.com

Online published on 7 July, 2018.

Abstract

Gastro-retentive drug delivery technology is designed to retain a drug in the upper gastrointestinal tract for a prolonged period of time to allow efficient absorption. This is important because almost 40% of all new drugs have poor bioavailability from the lower gastrointestinal tract. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region. Also, longer residence time in the stomach could be advantageous for local action in the upper part of the small intestine, for example treatment of peptic ulcer disease. Furthermore, improved bioavailability is expected for drugs that are absorbed readily upon release in the GI tract. These drugs can be delivered ideally by slow release from the stomach. The application of our unique gastro-retentive technology include: Use with drugs targeting absorption in the upper segment of the small intestine, Use with drugs targeting absorption in just the stomach, Suitable for high drug loads, Use with a range of drugs, including poorly soluble molecules.

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Keywords

Gastro-retentive drug delivery, Controlled drug delivery system, Gastric retention.

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