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Research Journal of Science and Technology
Year : 2018, Volume : 10, Issue : 2
First page : ( 125) Last page : ( 130)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2018.00018.9

Studies on Synthesis of Aromatic Schiff Bases. Part-V. Evaluation of Antifungal Potential of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone†

Patil C. J.1,*, Patil Manisha C.2,**, Patil Mrunmayee C.3

1Smt. G. G. Khadse College, Muktainagar, Dist-Jalgaon-425 306, Maharashtra, India

2Dr. A. G. D. Bendale Mahila College, Jalgaon-425 001, Maharashtra, India

3Dept. of Pharma. Sci. and Tech., Nathalal Parekh Marg, Institute of Chemical Technology, Matunga, Mumbai-400 019, Maharashtra, India

*Corresponding Author E-mail: drcjpatil@yahoo.com

**manisha1999@rediffmail.com

Online published on 7 July, 2018.

Abstract

The condensed reaction of aromatic ketone, 5-Chloro-2-hydroxy-4-methyl-acetophenone with aniline derivatives viz. 2, 3-Dimethyl-aniline, 2, 4-Dimethyl-aniline, 3, 4-Dimethyl-aniline and 2, 5-Dimethyl-aniline to yield a ketimines, CJ-1 to CJ-4. These were analyzed by employing the techniques such as thin layer chromatography(TLC) and UV-Vis spectra. After confirming their desired molecular studies, these novel ketimines were studied for their antifungal potential.

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Keywords

Ketimines, 5-Chloro-2-hydroxy-4-methyl-acetophenone, D. S. Trap, substituted anilines, TLC and UV-Vis, molar extinction coefficients(εmax) and antifungal potential.

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