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Research Journal of Science and Technology
Year : 2018, Volume : 10, Issue : 2
First page : ( 93) Last page : ( 97)
Print ISSN : 0975-4393. Online ISSN : 2349-2988.
Article DOI : 10.5958/2349-2988.2018.00013.X

Development and study of mixed surfactant microemulsion of Ofloxacin

Chandrakar Shashikant*, Roy Amit, Sahu Ram

Columbia Institute of Pharmacy, Raipur (C.G.) 493111, India

*Corresponding Author E-mail: shashikant.py@gmail.com

Online published on 7 July, 2018.

Abstract

Ofloxacin is fluoroquinolone derivative antibacterial agent and it is used for the treatment of bacterial infection into the eye as a eye drop. The eye drops are the most commonly used dosage form for the ocular route but it has several disadvantages like rapid wash out and dilution of the formulation leading to a low permeability of drug. The purpose of this work is to develop microemulsion formulation of Ofloxacin for ocular drug delivery. Pseudoternary phase diagram was prepared by using Span 20, Tween 80 (ratio of 1: 1 to 2: 1) as mixed surfactant, oleic acid as oil phase and double distilled water as aqueous media. The microemulsion OM1 to OM6 was prepared on the basis of microemulsion area present in pseudoternary phase diagram. The prepared microemulsion was evaluated for phase separation, globule size analysis, zeta potential polydispersity index, percentage drug content, viscosity, conductivity, %transmittance and pH.

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Keywords

Microemulsion, Span 20, Tween 20, Ofloxacin.

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