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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 9
First page : ( 1407) Last page : ( 1409)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00272.9

Method Development and Validation of Mebeverine HCl in Bulk Drugs by Using Spectrophotometric Method

Mahadik Parag S.1,2, Senthilkumar G. P.1,*

1Bharathi College of Pharmacy, Bharathinagara

2Pacific Academy of Higher Education and Research, Udaipur

*Corresponding Author E-mail: drsenn78@gmail.com

Online published on 12 January, 2017.

Abstract

In the present research a simple, accurate, precise and cost effective UV-Vis spectrophotometric method for the estimation of Mebeverine HCl in bulk was illustrated. The absorption maxima of the drug was found to be 220 nm in 0.1 N HCl. A linear response was observed in the range of 5–15 μg/ml with a regression coefficient of 1.0. Validation parameters were carried out as per the guidelines of International Conference for Harmonization. This method can be used in the industries for determination of Mebeverine HCl to analyze the quality of Mebeverine HCl without any interference.

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Keywords

Ultraviolet spectroscopy, Validation, Mebeverine HCl, Method development, Assay.

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