(18.233.111.242)
Users online: 2157    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 8
First page : ( 1223) Last page : ( 1228)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00233.X

Factors Influencing Rifampicin Autoinduction in Adult Pulmonary Tuberculosis Patients

Saranya1,4, Parthasarathy V2,*, Hariprasad B1, Rani H Shobha3

1Sri Ramachandra University, Chennai-600117

4Assistant Professor, School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai-600117

2Associate Professor, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, 608002

3Al-Ameen College of Pharmacy, Opp. Lalbagh Main Gate, Hosur Road, Bengaluru, Karnataka, 560027

*Corresponding Author E-mail: vapartha@yahoo.com

Online published on 12 January, 2017.

Abstract

Aim

To demonstrate autoinduction and determine the factors associated with inter-individual variability in autoinduction of rifampicin at induction phase.

Method

Pulmonary tuberculosis patients of either genders to be started on anti-tubercular therapy were enrolled into the study. Single blood sample at preinduction and induction phase was withdrawn by venipuncture. Serum rifampicin concentrations were estimated using LC-MS. All statistical analysis were carried out using IBM-SPSS 17.0 and graph pad prism 7.0.

Results

Significant reduction in rifampicin Cmax was observed after 28 days (<0.0001). Though all patients displayed significant reduction in Cmax, wide inter-individual variability was observed in change in rifampicin Cmax after 28 days (ΔCmax with a mean (SD) ΔCmax of 5.448 (2.79) mcg/ml. Multivariate analysis showed hepatic function and smoking history to be explanatory variables of inter-individual differences in rifampicin autoinduction. However, unexplained variability was observed possibly due to genetic and environmental factors.

Conclusion

In spite of factors identified in this study, unexplained variability observed in magnitude of autoinduction could be attributed to genetic polymorphisms in regulatory proteins of enzyme induction. Hence there is crucial need for genetic association studies, as decreased exposure to rifampicin is often associated with treatment failure and emergence of drug resistance strains.

Top

Keywords

Autoinduction, Cmax, polymorphisms, pulmonary tuberculosis, rifampicin.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
436,498,222 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.