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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 7
First page : ( 977) Last page : ( 981)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00187.6

Statins: Pleiotropic Effect

Ashna A, Jeena S, Vidhya PV, Venkateswaramurthy N.*, Sambathkumar R.

J.K.K. Nattraja College of Pharmacy, Kumarapalyam, Tamil Nadu, India

*Corresponding Author E-mail: venkateswaramurthy.n@jkkn.org

Online published on 15 October, 2016.

Abstract

Statins are most effective in reducing the plasma cholesterol level by inhibiting hydroxyl methyl glutaryl coenzyme A reductase. Emerging evidence suggest that statins exert other mechanism of action called Pleiotropic effects; which are plaque stability, endothelial function modification, thrombus formation etc. Therefore therapeutic potential of statins extends beyond lipid lowering. Correctly underlying these pleiotropic effect suggest a new method to prevent and treat wide variety of life threatening disorders. Thus statins has added a wide scope of potential targets ranging from acute coronary syndrome to other renal infections and neuroleptic disorders.

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Keywords

Pleiotropy, hypolipemic agents, HMG CoA Reductase Inhibitors.

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