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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 6
First page : ( 687) Last page : ( 690)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00128.1

Study on the adverse reactions of antipsychotics and therapeutic drug monitoring of olanzapine in psychiatric patients

Menaka K1,*, Sarumathy S2, Sivakumar T1

1Department of Pharmacy Practice, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandampalayam Post, Erode-638 052, Tamil Nadu, India

2Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai-600117, Tamil Nadu, India

*Corresponding Author E-mail: kmenaka1980@gmail.com

Online published on 21 July, 2016.

Abstract

Antipsychotics used in the treatment of psychotic disorders such as schizophrenia are generally associated with potential adverse effects. They mainly act by blocking dopaminergic uptake by binding to its receptors in the post synaptic nerve terminals. However their potential peripheral and extra pyramidal adverse effects have led to patient non-compliance of medications. Hence a clear understanding of the adverse effects associated with antipsychotic therapy could ultimately yield better therapeutic outcomes and increase patient adherence to medications. The study was designed to analyse the common adverse reactions caused by antipsychotic medications. Olanzapine was found to be associated with greater risk of adverse effects and hence the plasma concentration of olanzapine was monitored.

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Keywords

Psychotic disorders, Adverse drug reactions, Therapeutic drug monitoring, Olanzapine, Weight gain.

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