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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 5
First page : ( 541) Last page : ( 544)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00102.5

Cardioprotective activity of Limonia acidissima against Isoproterenol Induced Myocardial Infarction in Rats

Manohar Hasitha Diana1, Srinivasan D1, Sengottuvelu S2,*

1Pharmacology Department, Karpaga Vinayaga Institute of Medical Sciences and Research Centre, Madurantagam, Kancheepuram District, Tamilnadu, India

2Department of Pharmacology, Nandha College of Pharmacy and Research Institute, Erode, Tamilnadu, India

*Corresponding Author E-mail: sengt@rediffmail.com

Online published on 21 June, 2016.

Abstract

The objective of the current study is evaluate the cardioprotective activity of ethanolic fruit extract of Limonia acidissima against isoproterenol induced myocardial infarction in rats. The protective activity of Limonia acidissima was assessed by estimating the cardiac marker enzymes (Creatinine Phosphokinase and Lactate Dehydrogenase) and antioxidants enzymes (superoxide dismutase and Catalase). Thirty male Sprague-Dawley rats (180–220 gm) were randomly allocated in 5 groups of 6 each. Group I served as control, II to V animals were Isoproterenol (85mg/kg) induced myocardiaol infracted animals, pre treated with the reference control Lipistat (350mg/kg) and ethanolic fruit extract of Limonia acidissima (200 and 400 mg/kg). All the test drugs were administered orally for 15 days. On 16th day the blood was collected and subjected to the estimation of cardiac marker enzymes. The animals were sacrificed; hearts were homogenized and used for the estimation of antioxidant enzymes. The result shows that, Limonia acidissima significantly decreased the cardiac marker enzyme and increased the antioxidant enzymes. Limonia acidissima produced a dose dependent cardioprotective effect against the acute cardiac damage induced by Isoproterenol in rats. From the result it was concluded that, Limonia acidissima produced cardioprotective activity against isoproterenol induced cardiac damage in rats which was mediated by its antioxidant property.

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Keywords

Isoproterenol, Myocardial Infarction, Limonia acidissima, Creatinine Phosphokinase, Lactate Dehydrogenase, superoxide dismutase and Catalase.

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