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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 5
First page : ( 538) Last page : ( 540)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00101.3

Spectroscopic Estimation of Tenofovir Alafenamide, an antiretroviral drug

Kumar Pankaj*, Jacob Jane, Ajina Khadjeeth, Jazeela, Fathima

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Science, NITTE University, Deralakatte, Mangalore-575018, Karnataka, India

*Corresponding Author E-mail: pankajpgr@gmail.com

Online published on 21 June, 2016.

Abstract

Tenofovir Alafenamide is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. A simple, economical and accurate UV spectroscopy method was developed for Tenofoviral Afenamide in methanol and distill water in the ratio 20: 80. It obeyed Beer's law in the linearity range of 10–50 μg/ml at an absorption maxima of 267 nm. The results are reproducible with coefficient of variance less than 1%. The linear regression of absorbance on concentration with coefficient of regression of almost 1 indicates a good linearity between absorbance and concentration. The value of percentage relative standard deviation of less than 1% and low range of percentage error shows high degree precision and accuracy of the method.

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Keywords

Tenofovir Alafenamide, reverse transcriptase, tenofovir, HIV infection, UV spectroscopy.

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