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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 4
First page : ( 340) Last page : ( 344)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00060.3

Developmental Toxicity of Arsenic and its Underlying Mechanisms in the early Embryonic Development

Bavanilathamuthiah1, Lakshmanan Yoshitha2,  Purnima2,  Ratnaprabha3

1 Associate Professor, Department of Biotechnology, Sathyabama University, Chennai

2Biotech, Sathyabama University, Chennai

3Department of Animal Biotechnology, Madras Veterinary College, Chennai-7

Corresponding Author E-mail:

Online published on 6 June, 2016.

Abstract

Arsenic is an environmental contaminant. Laboratory studies suggests negative effects of arsenic on early embryonic development in rodents, including decreased weight, affected fetal brain development and altered postnatal behavior. The Zebrafish serves as an important vertebrate model for studying development, genetics, and diseases. The present study uses wild-type zebra fish embryos to explore the potential developmental toxicity of arsenic and its underlying mechanisms in the early embryonic development. At the molecular level VEGF, PERP are been evaluated as they play a key role in angiogenesis and tumor development.

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Keywords

Arsenic, Zebra Fish, toxicity, VEGF, PERP.

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