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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 3
First page : ( 227) Last page : ( 234)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00041.X

Prognostic Potential of Serum Biomarkers as Predictors for Cardiovascular Complications and Disease Progression in Chronic Kidney Disease Patients

Dhivya K*, Samuel Gideon George P

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University (VISTAS), Pallavaram, Chennai – 600117

*Corresponding Author E-mail: divyapharmd@gmail.com

Online published on 18 April, 2016.

Abstract

Aim

Chronic Kidney Disease (CKD) is characterized by progressive loss of kidney function over a period of time. The aim of the study is to determine the prognostic potential of serum biomarkers for cardiovascular complications and disease progression in chronic kidney disease patients.

Materials and Methods

This retrospective observational study was carried out in the nephrology department of a multispecialty hospital for a period of two months. Clinical and biochemistry reports of 499 CKD patients were collected in designed case report forms. All statistical analysis was carried out using International Business Machine (IBM) Statistical Package for Social Sciences (SPSS) 17.0.

Results

A direct correlation was observed between cardiac enzyme markers and phosphate levels. The product of Glycated Hemoglobin (HbA1c) and number of years of Diabetes Mellitus (DM) as predictive risk factors for development and progression of nephropathy (DN-CKD).

Conclusion

This study has attempted to evaluate altered serum biomarkers as potential prognostic factors of cardiovascular complication and progressive renal impairment in CKD patients. Further prospective studies are required to gain deep insights into this and thereby aid in making significant clinical decisions.

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Keywords

CKD, cardiomyocyte injury, biomarkers, hyperphosphatemia, diabetes.

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