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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 3
First page : ( 219) Last page : ( 226)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00040.8

Formulation and evaluation of extended release hard capsules of Furosemide

Mhanna Zain1,*, Dr. Ibrahim Wehad2, Dr. Hammad Tamim3

1Master Student, Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia

2Doctor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia

3Assistant Professor in Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syria. Syria-Lattakia

*Corresponding Author E-mail: zain.mhanna@gmail.com

Online published on 18 April, 2016.

Abstract

The aim of the present study is to prepare extended hard capsules of Furosemide using Eudragit RL, Eudragit RS and Ethyl cellulose individually in different ratios (6, 8, 12, and 15%) and different particle size of granules. The granules were prepared by wet granulation and then filled into capsules. The influence of different concentrations of polymer, type of polymer and granules size was studied. The prepared capsules assessed for their physicochemical properties and in-vitro drug release studies. The in vitro release data show that Ethyl cellulose has more retardation than Eudragits, and Eudragit RS retards drug release more than Eudragit RL does. In addition, higher concentration of polymer enhances the retardation better than lower concentration, and increasing the particle size of granules can alter the release of drug.

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Keywords

Hard capsules, Furosemide, Wet granulation, Ethyl cellulose, Eudragit RS, Eudragit RL.

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