(3.235.45.196)
Users online: 1648    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 3
First page : ( 205) Last page : ( 208)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00036.6

Evaluation of Hypoglycemic activity of different extracts of Bombax ceiba L. leaves

Bhargava S.1,*, Shah M.B.2

1Shrinathji Institute of Pharmacy, Upali Oden, Nathdwara-313301 (Rajasthan) India

2L.M. College of Pharmacy, Navrangpura, Ahmadabad, 380009 (Gujarat) India

*Corresponding Author E-mail: bhargavasushil7@gmail.com

Online published on 18 April, 2016.

Abstract

In the present work, Preliminary Phytochemical screening of Ethyl acetate, n-Butanol and Hydro-alcoholic (30:70) extracts of leaves was carried out. Acute toxicity study (ALD50) determined by Fixed dose (OCED Guideline No. 420) method of CPCSEA was adopted for toxicity studies. Hypoglycemic activity of these extract has been investigated on Normoglycemic Rats model and Oral Glucose Tolerance Test model. Result reveled that all three extract contain Flavonoids where as Alkaloids are absent. No Mortality observed during acute toxicity study at higher dose 2000 mg/kg bw so that 1/5th of higher dose i.e. 400mg/kg was used for biological evaluation. All the extracts showed significant hypoglycemic activity in Normoglycemic rats and OGTT model compare to Standard (Glibenclamide). Hydroalcoholic extract are superior to other in dose dependent manner. These findings suggest that the leaves of Bombax ceiba L have potential to lower the blood glucose level in experimental animals. Present research directs the importance of further research and development for its mechanism of action and molecular level study.

Top

Keywords

Bombax, Seemal, Hypoglycemic, OGTT, blood glucose level.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
437,025,628 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.