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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 2
First page : ( 170) Last page : ( 172)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00030.5

Rheumatoid Arthritis: An Autoimmune Disease Prevalent in Females

Srivastava Shikha*, Patel Shatish, Daharwal S.J., Singh Deependra, Singh Manju

University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh, 492010

*Corresponding Author E-mail: shikha_ceutics@yahoo.co.in

Online published on 9 March, 2016.

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder. Females are highly affected by the ill effect of arthritis due to misbalancing of sex hormone. Macrophages, T cells and B cells infiltrate the synovium that lines the joints, while the synovial fluid is dominated by neutrophils. Chronic inflammation leads to destruction of joint cartilage and bone. Several research findings indicate the involvement of sex hormones in RA. B cells and T cells promotes pathogenesis of arthritis. Marked pathogenesis of arthritis is dominant in female compared to male. Active involvement of T cells and B cells produces proinflammatory cytokines observed.

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Keywords

Rheumatoid Arthritis, sex hormones, B Cells, T Cells, cytokines.

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