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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 2
First page : ( 135) Last page : ( 138)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00022.6

Frequency of CYP1A1*2A Polymorphism in Syrian Children with Acute Lymphoblastic Leukemia

Mubarak Roushan1,*, Haddad Shaden1, Hamdan Outhman2

1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University

2Department of Pediatric Oncology and Hematology, Faculty of Medicine, Damascus University

*Corresponding Author E-mail: mansouroussama@yahoo.fr

Online published on 9 March, 2016.

Abstract

Although acute lymphoblastic leukemia (ALL) is the most common childhood cancer; factors governing susceptibility to this disease have not yet been identified. CYP1A1, a member of the cytochrome P450 (CYP) enzymes, plays a very important role in the metabolism of carcinogens. To explore the contribution of CYP1A1*2A polymorphism to ALL susceptibility, we conducted a case–control analysis in Syrian children. 70 children with acute lymphoblastic leukemia and 45 healthy control were studied. Genomic DNA was extracted, and restriction fragment length polymorphism (RFLP) based PCR was applied followed by digestion with MspI. Among 70 ALL patients, 8.6% were heterozygous for the CYP1A1*2A genotype compared with 4.4% of controls. The differences between the groups were found not to be statistically significant (OR 2.016; 95% CI 0.39–10.46). The results did not show any association between CYP1A1*2A genotypes and risk of ALL in Syrian children.

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Keywords

Cytochrome, CYP1A1*2A, polymorphism, ALL, susceptibility, PCR-RFLP, Syrian children.

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