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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 10
First page : ( 1641) Last page : ( 1646)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00329.2

Biomarker genes for gynaecological cancers

Sinha Vimlendu Bhushan*, Pandey Neha, Taneja Pankaj

Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh-201306, India

*Corresponding Author E-mail: vimlendusinha@gmail.com; vb.sinha@sharda.ac.in

Online published on 2 March, 2017.

Abstract

Cancer is disease of uncontrolled cell proliferation. In the current set of investigation, data available on Cbioportal was used for enlist the biomarker genes in breast, ovarian and cervical cancers. A total of 29 biomarkers having potential for long term use in therapeutic developments were identified. Few prominent ones for breast cancer like BRCA1, ER, PR and Her2/neu, Ki67, PCNA in breast cancer prognosis, M-CSF, FSH and SMRP, CA-125, HE-4, mesothelin and GST, FOLRI and ALDH1, p53, Ki67, PCNA for monitoring ovarian cancer, HPV E6, E7, MCM, CDC6, P16INK4A and PCNA. Ki67 for tumor aggressiveness and metastatic potential of cervical cancer was identified. The current manuscript elucidates the importance and detection of gynecological cancer using biomarkers as a fast and reliable way for early disease detection.

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Keywords

Cancer, Breast Cancer, Ovarian Cancer, Cervical Cancer, Biomarkers for Cancer.

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