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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 10
First page : ( 1593) Last page : ( 1595)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00315.2

Detection of blaCTX-M gene for ESBL production among clinical isolates of Escherichia coli

Sagar Sandra1, Dr. Gopinath P2

1BDS 2nd Year, Saveetha Dental College, Saveetha University, Chennai

2Senior Lecturer, Department Of Microbiology, Saveetha Dental College, Saveetha University, Chennai

Corresponding Author E-mail:

Online published on 2 March, 2017.

Abstract

Widespread spread of CTX-M type extended-spectrum beta-lactamases (ESBL) in E. coli strains which are resistant to extended-spectrum cephalosporins is the most remarkable example for rapid and global spread of plasmid mediated antimicrobial resistance in bacteria. The incessant spread and global prevalence of ESBL resistance poses a serious threat to the human health, as it is responsible for the narrowing of therapeutic options pertaining to infections. A sum of 20 uropathogenic isolates of E. coli were subjected for the antibiotic susceptibility pattern using different antibiotics and followed by the detection of blaCTX-M gene by PCR. By which, we found increased percentage of isolates were resistant to different antibiotics and 30% of them were having this gene. This indicates the prevalence of such antibiotic resistance gene in our region. Proper antibiotic policies would promote the patients health condition better.

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Keywords

E. coli, blaCTX-M, PCR, ESBL.

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