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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 10
First page : ( 1588) Last page : ( 1590)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00313.9

Detection of Serum Bactericidal activity of Clinical Isolates of Escherichia coli

Kumar K.R. Manoj1, Dr. Gopinath P2

1BDS 2nd Year, Saveetha Dental College, Saveetha University, Chennai

2Senior Lecturer, Department of Microbiology, Saveetha Dental College, Saveetha University, Chennai

Corresponding Author E-mail:

Online published on 2 March, 2017.


Serum resistant is appears to be an important virulence factor for the pathogenicity of different gram negative bacteria. The ability of microorganism to combat with human system by two mechanisms. The first is a specific immunity and the second is natural or non-specific resistance which does not occur for every invading microorganisms. (4) These two host defense mechanisms are present in every healthy hosts. However, they may differ among individuals depending on various known and unidentified factors. We have subjected 20 different clinical isolates of E. coli were analyzed for the ability to show serum bactericidal resistance. We have observed 2 isolates were shown to be resistant even after 24 hours of incubation. We conclude that the serum bactericidal activity is attributed by the effect of OMP, CPS and LPS of bacteria.


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