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Research Journal of Pharmacy and Technology
Year : 2016, Volume : 9, Issue : 1
First page : ( 11) Last page : ( 16)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2016.00003.2

Formulation and In-Vitro Evaluation of Floating Tablet of Gabapentin

Kar Nihar Ranjan1,*, Mahapatra Santosh Kumar2, Pothal Rajesh Kumar2, Meher Chaitanya Pr.1

1Department of Pharmaceutics, Gyan Vihar, Gayatri Institute of Science and Technology (GIST) Gunupur, Dist-Rayagada, 765022, Odisha

2Dept. of Pharmaceutics, Gayatri College of Pharmacy, Sambalpur, Odisha

*Corresponding Author E-mail: nihar_795@rediffmail.com

Online published on 9 March, 2016.

Abstract

The present research work is an attempt to formulate rate controlled drug delivery system of Gabapentin which is primarily absorbed from stomach, so by increasing the GRT of the drug, the bioavailability can be increased. As the drug is stable in acidic pH and mostly absorbed with in pH 1–3, as the stomach is the major absorption site for the drug. Basing on this fact the drug is made to float in the stomach using the mechanism of buoyancy. The study also includes various evaluation studies of Gabapentin tablet and the effect of processing variables on it. A possible interaction between drug and polymers are also investigated by FTIR and DSC studies. So, the present work has been under taken with the objective of designing and evaluation of floating oral sustained release tablet drug delivery system of Gabapentin by using HPMC K15, NaCMC, Xanthun gum, sodium bicarbonate, citric acid. Lactose, ethyl cellulose etc.

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Keywords

Gastric residence time (GRT), Gastric emptying time (GET), Sustained release, Drug release kinetics, Gabapentin.

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