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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 9
First page : ( 1269) Last page : ( 1275)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00230.9

Formulation and Evaluation of Mucoadhesive Buccal Films of Diclofenac Potassium

Uppala Annapurna*, Swapna Naga V, Devi Neelima R, Sheren Glory G, Kumar Kishore B

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, India, 522510

*Corresponding Author E-mail: annapurnampharm@rediffmail.com

Online published on 28 October, 2015.

Abstract

The development of mucoadhesive buccal films has increased dramatically over the past decade because it is a promising delivery alternative to various therapeutic classes of peptides, vaccines and nanoparticles. The present investigation highlights the formulation and evaluation of muco adhesive buccal films of Diclofenac Potassium. The mucoadhesive buccal films were prepared by solvent casting technique using polymers like Hydroxy Propyl Methyl Cellulose K4M, Ethyl cellulose and Carbopol 934P. The formulated films were evaluated for their physical parameters like surface area, folding endurance, swelling studies, drug content and In vitro release studies. The films of different formulations were found to have good physical appearance, surface area, optimum swelling capacity and drug release. In vitro drug release studies in pH 6.6 phosphate buffer showed a prolonged release for over five hours for all formulations. Formulation F1 containing HPMC K4M and Carbopol 934P was selected as best formulation. Therefore it can be concluded that the polymers and their combination influenced the physical properties of film and their release characteristics.

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Keywords

Diclofenac Potassium, buccal films, solvent casting technique, In vitro release studies, mucoadhesive polymers, buccal drug delivery.

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