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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 9
First page : ( 1250) Last page : ( 1258)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00227.9

Antimicrobial activity of newly Synthesized Pyrazolidine-3, 5-dione Substituted Thiochromene Derivatives

Choubey Ruchi1,*, Choubey Neelesh2, Garg Gopal3

1Department of Pharmacy, Gyan-Vihar University, Jaipur, Rajasthan

2School of Pharmacy, SSSUTMS, Sehore, M. P.

3Department of Pharmaceutical Chemistry, Oriental College of Pharmacy, Bhopal, M.P.

*Corresponding Author E-mail: ruchirkdf@gmail.com

Online published on 28 October, 2015.

Abstract

A series of novel Synthesis of 1-(2-Methyl-4-oxo-4H-thiochromene-8-carbonyl)-2-arylpyrazolidine-3, 5-dione (20–35) were synthesized with different aromatic hydrazides and evaluated for Anti-inflammatory and Analgesic activity. The structures of the compounds were confirmed by TLC, FTIR, 1H NMR, 13C NMR and Mass spectral data. The antibacterial and antifungal activity was performed by Broth Dilution Method. The results of antibacterial activity of the thio-chromene derivatives showed better antibacterial activity against various bacterial strains. Their antimicrobial activities against P. vulgaris, B. subtilis, S. epidermidis, P. mirabilis, M. luteus, S. aureus, S. hominis, B. pumilus, S. typhi, K. pneumonia, E. coli, B. cereus, P. aeruginosa, A. niger, A. awamori, C. albicans, A. alternate, M. canis, T. longiformis, A. flavus, F. solani, T. viride were investigated.

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Keywords

Antibacterial, Antifungal, Thiochromene, 3, 5-Pyrazolidine-dione.

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