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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 7
First page : ( 893) Last page : ( 900)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00145.6

Evaluation of Antibacterial action and Hepatoprotective efficiency of Solanum nigrum leaves extract on acetaminophen induced hepatotoxicity

Bhavani R.1, Geetha G.1, Santhoshkumar J.2, Rajeshkumar S1,*

1PG and Research, Department of Biochemistry, Adhiparasakthi College of Arts and Science, Kalavai-632506, Vellore District, Tamil Nadu, India

2Departmant of Biochemistry, Periyar University, Salem-636011, Tamil Nadu, India

*Corresponding Author E-mail: ssrajeshkumar@hotmail.com, j3ssrajesh@gmail.com

Online published on 28 October, 2015.

Abstract

Solanum nigrum leaf is one of the most important greens in throughout the world. Plants are playing a vital role in hepatoprotective activity. In this present investigation we used Solanum nigrum for the antimicrobial activity and hepatoprotective activity against acetaminophen induced liver toxicity in male albino rats. The important chemical groups present in the aqueous extract canbe determined using Fourier transform infrared spectroscopy (FT-IR). Zone of inhibition in bacterial spread plate showing a antimicrobial property of the plant extract. The aqueous extract of Solanum nigrum significantly decreases the serum enzyme alanine amino transferase (ALT), asparate amino transferase (AST), triglycerides (TGL), total cholesterol (TC) and significantly increased the total protein level. Silymarin (100 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity. The morphology of liver cells clearly indicating the treatment of Solanum nigrum against acetaminophen induced liver damage near to normal cells.

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