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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 7
First page : ( 836) Last page : ( 840)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00136.5

Development of a poly (ɛ Caprolactone) based nanoparticles for oral delivery of Quercetin

Kumar Dinesh V.*, Verma Priya Ranjan Prasad

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India

*Corresponding Author E-mail: thendral.din007@gmail.com

Online published on 28 October, 2015.

Abstract

Quercetin loaded Poly (ɛ caprolactone; PCL) nanoparticles were prepared by the solvent displacement method. The influences of formulation variables (polymer and surfactant concentration) were investigated. The results of formulations F1-F9 showed Particle size (nm) in a different medium ranged from 189.10 ± 0.28 to 252.14 ± 2.32 in 0.1 N HCl and 184.06 ± 3.84 to 288.54 ± 2.86 in phosphate buffer pH 7.4, Dissolution efficiency (%) of 46.42 ± 5.42 to 72.20 ± 0.68 and drug loading (%) of 7.18 ± 0.25 to 9.27 ± 0.50. High Resolution-Transmission Electron Microscopy image represents the spherical and smooth surface of nanoparticles. The results suggested that, quercetin loaded polymeric nanoparticles may be the viable strategy for controlled release for more than 48 hours, and improves the physical stability of quercetin.

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Keywords

Quercetin, Poly (ɛ caprolactone), solvent displacement method, HR-TEM, nanoparticles.

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