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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 6
First page : ( 669) Last page : ( 673)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00105.5

Hepatoprotective activity of Chenopodium album Linn. in Ethanol induced Hepatotoxicity in Rats

Karwani Gauri*, Sisodia Siddhraj S.

Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, 313 001, India

*Corresponding Author E-mail: sandykarwani@yahoo.com

Online published on 30 July, 2015.

Abstract

The present study was conducted to evaluate the hepatoprotective activity of methanolic extracts of Chenopodium album Linn. against ethanol induced liver damage in rats. The ethanolic extract of Chenopodium album Linn.(200, 400 and 600 mg/kg) was administered orally to the animals with hepatotoxicity induced by ethanol (3.76 g/kg). Silymarin (200 mg/kg) was given as reference standard. All the test drugs were administered orally. The plant extract was effective in protecting the liver against the injury induced by ethanol in rats. This was evident from significant reduction in Biochemical parameters i.e., aspartate amino transferase (AST or SGOT), alanine amino transferase (ALT or SGPT), alkaline phosphatase (ALP), total bilirubin, total cholesterol, peroxidation (LPO), superoxide dismutase (SOD), Catalase and glutathione and total protein were analyzed according to the reported methods. It was concluded from the result that the ethanolic extract of Chenopodium album Linn. possesses hepatoprotective activity against ethanol induced hepatotoxicity in rats.

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Keywords

Hepatoprotective, ethanolic extract of Diospyros melanoxylon leaves, Silymarin, Biochemical parameters, Histopathology.

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