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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 4
First page : ( 395) Last page : ( 403)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00067.0

Once a daily Tablet Formulation and In Vitro Evaluation of HPMC Based Intra Gastric Floating Tablet of Levofloxacin

Gangane P.S1,*, Sapkal S. B.2, Welankiwar A.S.2, Magar P.S.2, Bhusari D.V.2

1Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur

2Department of Pharmaceutics, IBSS College of Pharmacy, Malkapur, Dist. Buldana

*Corresponding Author E-mail: abhi123welankiwar@gmail.com

Abstract

The aim of this study was to develop a new intra-gastric floating tablet for controlled delivery of Levofloxacin for the treatment of peptic ulcer disease caused by Helicobacter pylori (H. pylori). The method of preparation is direct compression method. HPMC, K-grade and effervescent material sodium bicarbonate formed the floating layer. The release layer contained Levofloxacin and various polymers such as HPMC-K15M, HPMC-K100M, PVP-K30 and MCC in combination with the drug. The in vitro drug release was studied in pH 1.2 HCl using USP dissolution Apparatus II at 50 rpm. Zero-order, first-order, Higuchi and Korsmeyer et al. models were used to estimate the kinetics of drug release. Optimized formulation released approximately 98% drug in 12 h in vitro, while the floating lag time was 49 sec and the tablet remained floatable throughout all studies. Optimized formulation (D3) followed the Korsmeyer and Peppas model and showed no significant change in physical appearance, drug content, floatability and invitro dissolution pattern after storage at 45°C/75% RH for three month.

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Keywords

H. pylori infection, Methocel matrices, swelling index, Data analysis.

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