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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 3
First page : ( 276) Last page : ( 279)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00046.3

Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases

Lunkad A.S.*, Kothawade S.N., Jadhav D.V., Chaudhari P.S., Bornare S.P.

SCSSS's Sitabai Thite College of Pharmacy, Shirur (Ghodnadi), Dist-Pune

*Corresponding Author E-mail: amit.lunkad15@gmail.com

Online published on 2 May, 2015.

Abstract

Benzofuran nucleus frequently occurs in natural products. In the present course of study an attempt is made for synthesis of new Benzofuran derivatives. 5-chloro-2-hydroxy acetophenone 2 was prepared by the Fries rearrangement with anhydrous aluminium chloride at 1300c for 3 hrs. The compound 2 was treated with chloroacetone in presence of anhydrous acetone and potassium carbonate gave 5-chloro-3-methyl-2-acetyl Benzofuran 3. Compound 3 underwent condensation with aromatic aldehyde and aromatic amines to furnished chalcone and Schiff derivatives 4a-e and 5a-e respectively. The synthesized compounds were screened for their antimicrobial activities.

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Keywords

5-chloro-2-hydroxy acetophenone, Chalcone, Schiff base, Antimicrobial activity.

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